Joint conference of the

3rd Annual HPSG meeting and the 9th ALPD symposium


21-23 NOVEMBER 2014, Novotel Hotel SZEGED


programme: HPSG - ALPD

registration form



21 NOVEMBER 2014 (Friday)


8:00 – 9:00 Breakfast meeting with the International guests

István Vedres Meeting Room

Moderator: Péter Hegyi (Szeged, Hungary)

Brain storming – by invitation only


9:30 – 10:00 Opening of the 3rd HPSG meeting

Lajos Tisza Meeting Room

Chairs:Péter Hegyi (Szeged, Hungary), Miklós Sahin-Tóth (Boston, USA),

István Hritz (Budapest, Hungary)

Sponsors: Sager Pharma – Abbott – Berlin Chemie – Szekerke Mária RA


9:30 – 9:40 Welcome Notes by the sponsors

9:40 –10:00 Péter Hegyi (Szeged, Hungary)

HPSG: History and Future perspectives


10:00 – 12:10 Focus on Pediatric Pancreatitis

Lajos Tisza Meeting Room

Chairs:Gábor Veres (Budapest, Hungary), Csaba Bereczki (Szeged, Hungary), Natália Lásztity (Budapest, Hungary)

Session introduction by Péter Hegyi (Szeged, Hungary)


10:00 – 10:30 Maisam Abu-El-Haija (Cincinnati, USA)

AP in Children

10:30 – 10:40 Aliye Uc (Iowa, USA)

Introduction of INSPPIRE

10:40 – 11:10 Aliye Uc (Iowa, USA)

ARP and CP in Children

11:10 – 11:40 Mark Lowe (Pittsburgh, USA)

Treatment of ARP and CP with a focus on TP-IAT

11:40 – 12:10 Heiko Witt (Münich, Germany)

Genetic mutations in pediatric CP patients in Germany.






12:50 – 13:20 Data Administration (lunch session)

Lajos Tisza Meeting Room

Chair:Andrea Szentesi OPR Director (Szeged, Hungary)


12:50 13.20    Andrea Szentesi OPR Director (Szeged, Hungary)

Technical guideline for the web based data registry




13:30 – 15:30 Pancreas Genetic Testing

Lajos Tisza Meeting Room

Chairs:Márta Széll (Szeged, Hungary), Balázs Németh (Szeged, Hungary)

Session introduction by Miklós Sahin-Tóth (Boston, USA)


13:30 – 14:00 David C. Whitcomb (Pittsburgh, USA)

Genetics of pancreatitis with a focus on pancreatic ducts.

14:00 – 14:30 Miklós Sahin-Tóth (Boston, USA)

Genetics of pancreatitis with a focus on trypsin activation.

14:30 – 15:00 Jonas Rosendahl (Leipzig, Germany)

Genetics of alcoholic and non-alcoholic pancreatitis.

15:00 – 15:30 Federico Canzian (Heidelberg, Germany)

Genetic susceptibility to pancreatic cancer.






16:00 – 18:00 HPSG meeting

Lajos Tisza Meeting Room

Chairs:Áron Vincze (Pécs, Hungary), Balázs Kui (Szeged), Richard Szmola (Budapest, Hungary)

Session introduction by István Hritz (Budapest, Hungary)


16:00 – 16:10 Péter Hegyi (Szeged, Hungary)

Working rules of HPSG

16:10 – 16:25 István Hritz (Budapest, Hungary)

HPSG Cohort: AP

16:25 – 16:40 Ákos Szűcs (Budapest, Hungary)

HPSG Cohort: CP

16:40 – 16:55 Andrea Párniczky (Budapest, Hungary)

HPSG Cohort: PP

16:55 – 17:10 Zsuzsanna Kahán (Szeged, Hungary)

HPSG Cohort PC


17:10 – 18:00 Prospective studies - Central and Eastern European Working


Lajos Tisza Meeting Room

Chairs:Ewa Małecka-Panas (Łódź, Poland), Dimitry Bordin (Moscow, Russia), Natalya Gubergrits (Donetsk, Ukraine)



17:10 – 17:30 Péter Hegyi (Szeged, Hungary)

Introducing the International Centres, future perspectives

17:30 – 17:45 István Hritz (Budapest, Hungary)

Introduction of EASY trial

17:45 – 18:00 Fanni Zsoldos (Budapest, Hungary)

Introduction of PINEAPPLE trial

18:00 – 18:15 Andrea Párniczky (Budapest, Hungary)

Introduction of APPLE trial

18:15 – 18:30 Zsolt Dubravcsik (Kecskemét, Hungary)

Introduction of PREPAST trial


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11:30 – 15:00 Paralel meeting for the Hungarian data administrators

(in Hungaran)

Párhuzamos előadás magyar adminisztrátorok részére

István Vedres Meeting Room


11.3012.15    Ebéd

12.1512.45    Szentesi Andrea OPR igazgató (Szeged, Hungary)

OPR és weboldal újdonságok, induló prospektív vizsgálatok



13.3015.00    Szentesi Andrea OPR igazgató (Szeged, Hungary)

Új űrlapok bemutatása, feltöltéssel kapcsolatos kérdések




20:00 Joint Dinner of HPSG and the Faculty of ALPD

Szeged H6720 Roosevelt tér 14 – Fisher’s restaurant





22-23 NOVEMBER 2014 – 9th ALPD symposium


22 NOVEMBER 2014 (Saturday)



800 – 810Opening of the 9th ALPD meeting

SESSION 1 : State of the Art Lectures “ Overview on alcohol-induced pancreatic and liver diseases”


810 – 825Alcoholic Liver Disease: Do Genes or Environment Matter More?

Samir Zakhari (USA)

825 – 850Mechanisms by which alcohol predisposes to pancreatitis: an overview

Anna Gukovskaya (USA)

850 – 915Morphogens, metabolic reprogramming, and alcoholic liver disease

Hidekazu Tsukamoto (USA)


SESSION 2 : “Selected oral presentations (1-3)”

915 - 945


945 – 1000Coffee break


SESSION 3 : “Pancreatic and liver cancer development and therapy”

1000 – 1025Pancreatic cancer - the microenvironment needs attention too

Minoti Apte (Australia)

1025 – 1050Cell cycle regulators are key factors in liver pathology

Luis Fajas (France)

1050 – 1115Neddylation and liver cancer: new therapeutical approach

Maria Luz Martinez-Chantar (Spain)

1115 – 1140Ca2+, cAMP and migration of pancreatic cancer cells

Alexei Tepikin (UK)

1140 – 1205Novel therapeutics for pancreatic and liver cancer

Ashok Saluja (USA)


1205 – 1330Lunch and poster viewing


SESSION 4: “The effects of alcohol on Ca2+ signalling and on cellular homeostasis”


1330 – 1355NFAT isoform activation by sub-cellular calcium signals

Anant Parekh (UK)

1355 – 1420Pathological Ca2+ signals, their effects and how to prevent them

Ole Petersen (UK)

1420 – 1445Alcohol, calcium signaling, and secretion in cholangiocytes

Michael Nathanson (USA)

1445 – 1510Acid sphingomyelinase in steatohepatitis

José Carlos Fernández-Checa (Spain)



SESSION 5: “Selected oral presentations (4-6)”

1510 – 1540


1540 – 1600Coffee break


SESSION 6: “Epithelial physiology and the role of epithelial cells in alcohol induced tissue damage”


1600 – 1625Translocation between PI(4,5)P2 microdomains determines STIM1 conformation and gating of Orai1

Shmuel Muallem (USA)

1625 – 1650The role of pancreatic ducts in the pathogenezis of acute pancreatitis

Zoltán Rakonczay Jr. (Hungary)

1650 – 1715Function and repair of dental enamel - potential role of epithelial transport processes of ameloblasts

Gábor Varga (Hungary)


1930 – 2230Welcome reception and dinner



23 NOVEMBER 2014 (Sunday)


SESSION 7: “Genetics of alcohol-related pancreatic diseases”

800 – 825How does alcohol contribute to pancreatic diseases?

David Whitcomb (USA)

825 – 850Genetic clues towards a mechanism of alcoholic chronic pancreatitis

Miklós Sahin-Tóth (USA)

850 – 915Genetic susceptibility factors for alcohol-induced chronic pancreatitis

Marcus Lerch (Germany)

915 – 940Genetic models of pancreatitis: how CF animal models can help us understand the pathogenesis?

Aliye Uc (USA)


SESSION 8: “Selected oral presentations (7-9)”

940 – 1010


1010 – 1025Coffee break


SESSION 9: “Alcohol-induced inflammation and immune response - Liver”

1025 – 1050Metabolic and microbial danger signals in alcoholic liver disease

Gyöngyi Szabó (USA)

1050 – 1115Opposing role of type I vs. type II NKT cells in alcoholic liver disease—implications for novel intervention

Vipin Kumar (USA)

1115 – 1140Cellular and molecular drivers in alcoholic hepatitis

Ramon Bataller (USA)

1140 – 1205Circadian Clock Control of Alcoholic Liver Disease by Nuclear Receptor Signaling

Li Wang (USA)


1205 – 1330Lunch and poster viewing


SESSION 10: “Alcohol-induced inflammation and immune response - Pancreas”


1330 – 1355Stephen Pandol (USA)

1355 – 1420Involvement of Alcohol and Fat in Acute Pancreatitis: a Dangerous Liaison

David Criddle (UK)

1420 – 1445Fat in pancreatitis

Vijay Singh (USA)


SESSION 11: “Alcohol-related mitochondrial dysfunction”

1445 – 1510György Hajnóczky (USA)

1510 – 1535Joannes Hoek (USA)

1535 – 1600The crucial role of mitochondrial damage and consequent breakdown of bioenergetics in acute pancreatitis

Peter Hegyi (Hungary)


1600 – 1615Coffee break


SESSION 12: “Non-alcoholic and alcoholic fatty liver diseases I.”

1615 – 1640Bile acid signalling and non-alcoholic fatty liver disease

Peter Jansen (The Netherlands)


1640– 1705The role of alcohol-induced liver hypoxia

Yatrik Shah (USA)

1705 – 1730The role of the hepatic endocannabinoid system in alcohol-related pathologies

George Kunos (USA)


1730 – 1755NADPH oxidases in alcoholic liver disease

Natalie Torok (USA)

1755 – 1800Closure of the meeting


2000 - 2300Gala dinner, award presentations



End of Programme



Funding for this conference was made possible (in part) by Grant R13AA20691 from the National Institute on Alcohol Abuse and Alcoholism (NIAAA). The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention by trade names, commercial practices or organizations imply endorsement by the U.S. Government.